Clec9a ligand
WebOct 17, 2012 · CLEC9A, a novel C-type selectin receptor on a subset of DCs, plays an important role in cross-presentation of dead cell-associated antigens. Interestingly, we detected high expression of CLEC9A ligand on autophagosomes. WebFeb 21, 2024 · Therefore, we designed bispecific antibodies that target CD40 activation preferentially to dendritic cells, by coupling the CD40 agonist arm with CD11c-, DEC-205- or CLEC9A-targeting arms. These...
Clec9a ligand
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WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebCD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the …
WebDec 2, 2024 · At lower pH, both mouse and human Clec9A adopt a reduction-resistant dimer conformation. This reduction-resistant conformation promotes cross-presentation of dead cell-derived Ag, although it does not affect the ability of Clec9A to bind its ligand F-actin, to signal through Syk kinase or to undergo internalization (Hanč et al., 2016). Thus ... WebType 1 conventional dendritic (cDC1) cells are necessary for cross-presentation of many viral and tumor antigens to CD8 + T cells. cDC1 cells can be identified in mice and …
Webet al. (2010) also found Clec9A+ DCs The murine dendritic cell network comprises multiple subsets with distinct functions, but few of their human counterparts have been described. New data now reveals the likely human equivalent of the mouse DC subset special-ized in cross-presentation. WebDNGR-1 (CLEC9A) is particularly interesting because of its restricted pattern of expression in DCs that may be exploited for cancer therapy. It has recently been revealed that DNGR-1 binds damaged or dead cells via …
WebMar 8, 2012 · CLEC9A is a recently discovered C-type lectin receptor involved in sensing necrotic cells. In humans, this receptor is selectively expressed by BDCA3(+) myeloid …
WebMar 17, 2016 · The crystal structure of CLEC9A was reported in the apo form (PDB ID: 3VPP) (Zhang et al. 2012). The putative ligand recognition site of CLEC9A is similar to those of other CLRs. Two mutations located at this face, W131A and W227A, disrupt the ability to bind F-actin, supporting the idea that this face is a ligand recognition site. current through mini dc motorWebCLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand (s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk. Product Details Technical data sheet Product Details Isotype Control charnwood tri clubWebWe have identified this Clec9A ligand as a filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins. We have determined the crystal structure of the human CLEC9A C-type lectin domain and propose a functional dimeric structure with conserved tryptophans in the ligand recognition site. Mutation of ... charnwood trucksWebDec 2, 2024 · Clec9A recognition of dead cells via binding to its ligand F-actin, requires conserved tryptophan residues located in the Clec9A … current through resistorWebApr 20, 2012 · Clec9A recognizes a conserved component within nucleated and nonnucleated cells, exposed when cell membranes are damaged. We have identified this … current through resistors in seriesWebThe natural ligand for CLEC9A is the intracellular cytoskeletal protein F-actin that becomes exposed on necrotic cells. In contrast to other C type lectins that signal through NF-κB and induce an inflammatory signature, CLEC9A signals through spleen tyrosine kinase (SYK) after F-actin binding. charnwood training group ltdWebLigand–receptor interactions in CC with different histologic subtypes and HPV infection statuses. A) Dot plots demonstrate selected ligand–receptor interactions between tip cells and other endothelial cells, respectively, in HPV-positive SCC, HPVA ADC and NHPVA ADC. ... [30, 41] In terms of DCs, we identified that CLEC9A+ DCs exerted ... charnwood tree services