WebJul 19, 2024 · Moreau P, Sonneveld P. Daratumumab (DARA) maintenance or observation (OBS) after treatment with bortezomib, thalidomide and dexamethasone (VTd) with or without DARA and autologous stem cell transplant (ASCT) in patients with newly diagnosed multiple myeloma (NDMM): CASSIOPEIA part 2. ... As monotherapy, for the treatment … WebNov 29, 2024 · DARA is a CD38-targeting IgG1κ monoclonal antibody with on-tumor and immunomodulatory mechanisms of action. Based on the demonstrated efficacy and …
Phase II study of daratumumab (DARA) monotherapy in patients …
WebDec 3, 2015 · DARA acts through multiple immune effector-mediated mechanisms, including complement-dependent cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and antibody-dependent cellular phagocytosis. WebAug 29, 2024 · From its introduction as monotherapy for multiple myeloma to its increasing utilization as a combination agent for relapsed or refractory multiple myeloma, daratumumab continues to be a major tool in the hematologist’s treatment armamentarium (See original Daratumumab Spotlight).Its indications in multiple myeloma include use as a single … penrith panthers draw 2023
Cancers Free Full-Text Current Main Topics in Multiple Myeloma
WebDec 4, 2024 · Dara, a human IgGκ monoclonal antibody that targets CD38, is approved as monotherapy and in combination with Vd, Rd, and pomalidomide-d for the treatment of … WebMar 29, 2024 · Conclusions: Daratumumab monotherapy had a favorable safety profile and encouraging efficacy in patients with heavily pretreated and refractory myeloma. (Funded by Janssen Research and Development and Genmab; ClinicalTrials.gov number, NCT00574288.). Source: PubMed. Sponsors and Collaborators. WebMar 27, 2024 · DARA is a first-in-class, CD38-targeting IgGk1 MoAb composed of two identical pairs of light and heavy chains that bind through an Fc tail to surface Fcγ … penrith panthers club address