Irf5 protein half-life

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August undefined, 2024

WebThe IRF5 protein from these reaction mixtures was further purified and analyzed by mass spectrometry, which revealed that peptides containing phosphorylated Ser-445 and Ser-434 of mIRF5 were greatly enriched in the reactions that contained IKKβ, whereas the total counts of mIRF5 peptides were similar in both reactions ( Fig. 3 B and C and Fig. S2 … WebThe protein produced from the IRF5 gene, called interferon regulatory factor 5 (IRF5), acts as a transcription factor, which means that it attaches (binds) to specific regions of DNA and …

RNAi Screen and Proteomics Reveal NXF1 as a Novel Regulator of IRF5 …

IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist. The regulatory and repression regio… WebApr 17, 2007 · These alterations in IRF5 protein structure and expression levels presumably shape the IRF5 transcriptional cascade and downstream immune responses. It has been shown that IRF5 is activated by Toll-like receptors 7/9 and type 1 IFN signaling and that, upon stimulation, different IRF5 protein isoforms differentially activate transcription of ... sims cc steam

Inhibition of IRF5 cellular activity with cell-penetrating peptides ...

WebApr 17, 2007 · Estimates for the half-life of these transcripts, based on regression curves, were: 342 ± 88 min for the short allele and 125 ± 21 min for the long allele. By comparison, … WebMay 30, 2024 · Background. Community-acquired pneumonia (CAP) is a common disease with significant morbidity and mortality. Interferon regulatory factor 5 (IRF5), which induces type I interferons (IFNs) and cytokines such as interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-10, and interferon gamma-induced protein (IP)10, is a key transcription factor … WebRecombinant Human IRF5 protein See all IRF5 proteins and peptides Purity > 95 % SDS-PAGE. Greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE. Endotoxin … r command to pull whole number from decimal

Expression Levels of Interferon Regulatory Factor 5 (IRF5) and …

Irf5 protein half-life

IRF5 Gene - GeneCards IRF5 Protein IRF5 Antibody

WebSep 10, 2024 · IRF5 is highly expressed in not only monocytes and macrophages but also in B cells and dendritic cells. Its expression in macrophages can be upregulated in response to the inflammatory … WebMar 21, 2024 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel …

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WebApr 16, 2002 · Q13568 · IRF5_HUMAN Protein Interferon regulatory factor 5 Gene IRF5 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids … WebThe transcription factor interferon regulatory factor 5 (IRF5) plays essential roles in pathogen-induced immunity downstream of Toll-, nucleotide-binding oligomerization …

WebIn the absence of TRAIL, little change in IRF5 protein levels were observed at 4 h post-CHX treatment (Fig. 4A, 6, and 7C); however, in the presence of TRAIL and CHX, IRF5 degradation was readily ... WebMar 28, 2007 · We also found, in the polyadenylation site of IRF5, an SNP (G>A) determining the length of the 3′-UTR. The A allele leads to a short 3′-UTR, while the G allele encodes for a 1.5-kb long 3′-UTR and has 2 strong AREs known to be responsible for short half-life and rapid RNA degradation . Messenger RNA with a shorter 3′-UTR bearing no such ...

WebIRF5 protein expression summary - The Human Protein Atlas. IRF5. PROTEIN SUMMARY SECTION OVERVIEW RNA DATA ANTIBODY DATA. IRF5 INFORMATION. Proteini. Full gene name according to HGNC. Interferon regulatory factor 5. Gene namei. Official gene … IRF5. SECTIONS. TISSUE BRAIN SINGLE CELL TYPE TISSUE CELL TYPE … This section contains Pathology information based on mRNA and protein … In total, 16465 of all human protein coding genes (n=20090) are detected in the … Protein tyrosine phosphatase non-receptor type 18: 0.7333: 64: COTL1: Coactosin … Expression of IRF5 in skin tissue. Antibody staining with HPA046700 and … Expression of IRF5 in breast tissue. Antibody staining with HPA046700 and … IRF5 protein expression summary. We use cookies to enhance the usability of our … Expression of IRF5 in testis tissue. Antibody staining with HPA046700 and … Expression of IRF5 in urinary bladder tissue. Antibody staining with HPA046700 and … Expression of IRF5 in appendix tissue. Antibody staining with HPA046700 and … WebOct 29, 2024 · The transcription factor interferon regulatory factor-5 (IRF5) plays an important role in innate immune responses via the TLR-MyD88 (Toll-like receptor - …

WebJul 19, 2024 · IRF5 protein, human Ifnar1 protein, mouse Immunoglobulin G Interferon Regulatory Factors Irf5 protein, mouse Transcription Factors Receptor, Interferon alpha-beta lyn protein-tyrosine kinase src-Family Kinases

WebMar 29, 2024 · The Interferon regulatory factors (IRFs) are a family of transcription factors that play pivotal roles in many aspects of the immune response, including immune cell development and differentiation and regulating responses to pathogens. Three family members, IRF3, IRF5, and IRF7, are critical to production of type I interferons downstream … sims cc teen clothesWebInterferon regulatory factor 5 (IRF5) is a crucial transcription factor in a number of immune and homeostatic processes, including host defense against pathogens, tumorigenesis, and autoimmunity. sims cc toddler hairWebInterferon regulatory factor 5 (IRF5) belongs to a family of transcription factors, originally implicated in antiviral responses and interferon production. However, studies conducted … r company\u0027sWebMay 19, 2024 · IRF5 is activated by phosphorylation and ubiquitination events downstream of pattern recognition receptors (PRRs), e.g., nucleotide-binding oligomerization domain-containing protein 2 (NOD2), Toll-like receptor 2 (TLR2), and TLR4, and directly regulates many cytokines associated with IBD (IL-1β, IL-6, IL-10, IL-12, IL-23, and TNF), placing IRF5 … sims cc teethWebJun 2, 2024 · Stimulation with TLR7 ligand enhances formation of IRF5-NXF1 protein complexes. Gain or loss-of-function experiments revealed NXF1 selectively regulates TLR7-driven IRF5 transcriptional activity ... r community\\u0027sWebMar 21, 2024 · IRF5 (Interferon Regulatory Factor 5) is a Protein Coding gene. Diseases associated with IRF5 include Systemic Lupus Erythematosus 10 and Inflammatory Bowel Disease 14 . Among its related pathways are Toll-like receptor signaling pathway and Interferon gamma signaling . r comp vst freeWebOct 5, 2008 · The physiological importance of IRF5 makes it an important prototype for investigating regulation of IRF proteins. IRF proteins, including IRF5, comprise two major domains, an N-terminal DNA... r compute rolling sum