Spns2 chemokine
Web14 Nov 2024 · It is formed by one of two sphingosine kinases (SphKs), SphK1 and SphK2. These enzymes largely exert their various biological and pathophysiological actions … WebSPNS2; Magic™ Membrane Protein Human SPNS2 (Sphingolipid transporter 2) Full Length; Magic™ Membrane Protein Human SPNS2 (Sphingolipid transporter 2) Full Length …
Spns2 chemokine
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Model organisms have been used in the study of SPNS2 function. A conditional knockout mouse line, called Spns2 was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Animals underwent a standardized phenotypic screen to determine the effects of deletion. Twent… Web29 Mar 2024 · SPNS2 SPNS lysolipid transporter 2, sphingosine-1-phosphate [ (human)] Gene ID: 124976, updated on 29-Mar-2024 Summary The protein encoded by this gene is …
WebSLF1081851 (TFA) is a Spns2 inhibitor, inhibits S1P release ( IC50 =1.93 μM). SLF1081851 (TFA) plays a key role in development and immune system [1] [2] . Sphingosine 1 … http://probechem.com/products_SLF1081851.html
WebGene target information for SPNS2. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Web14 Nov 2016 · Natural killer (NK) cells are located at the periphery of the lymph node, predominantly in the medulla, and we found that expression of SPNS2, expression of the …
WebWe have established that a gradient of the signaling lipid sphingosine 1-phosphate (S1P) is required to guide T cells out of lymphoid organs. We have also identified many of the key …
WebWe previously showed that targeted expression of SOCS-1 (Suppressor of Cytokine Signaling-1) to pancreatic beta cells (SOCS-1-transgenic (Tg) islets) from C57BL6/J mice delays islet allograft rejection in BALB/c mice. In the present study, we extend these observations to investigate the mechanism of this delayed rejection. hospital bed heated airWeband Spns2 provide redundant sources of S1P to maintain vascular development and homeostasis. To understand the roles of Mfsd2b and Spns2 in S1P export and to address … hospital bed height from floorWeb5 Oct 2024 · Protein Spinster homolog 2 (Spns2) is a sphingosine-1-phosphate (S1P) transporter that releases S1P to regulate lymphocyte egress and trafficking. Global … hospital bed hire aucklandWebSpns2 in LECs is essential to maintain S1P gradient between lymphatic tissue and lymph and governs lymphocyte migration and survival (60)(61) (62), suggesting Spns2 is … psychiatry residency forumWeb9 Jul 2024 · Spns2 f/f and ECKO‐Spns2 blood was collected via intracardiac puncture in EDTA to a final concentration of 50 mmol/L. Plasma was obtained by centrifugation (1000 … hospital bed hire newcastleWeb21 Apr 2024 · SPNS2 in βENaC mice was sharply reduced (38%, p < 0.05) and lost apical localization at sites of mucus obstruction. A significant (34%; p < 0.01) decrease in epithelial SPHK2 was also noted at mucus obstruction sites. Conclusion These results support that mucus obstruction may enhance NLRP3 inflammasome activation and dysregulated S1P … psychiatry residency electivesWeb4 Jun 2012 · The activities of S1P as a chemokine and a second-messenger are critically dependent on the S1P concentrations in the different cellular compartments, the tissue … psychiatry research: neuroimaging 影响因子